PTMS (gene)

PTMS
Identifiers
Aliases	PTMS, ParaT, parathymosin
External IDs	OMIM: 168440; MGI: 1916452; HomoloGene: 136762; GeneCards: PTMS; OMA:PTMS - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	6,770,952 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	124,897,066 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; right hemisphere of cerebellum; ; right lobe of liver; ; body of uterus; ; ganglionic eminence; ; muscle layer of sigmoid colon; ; popliteal artery; ; tibial arteries; ; right ovary; ; left ovary;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; ventricular zone; ; lactiferous gland; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding;
Cellular component	nucleus;
Biological process	DNA replication; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	5763
	69202
	ENSG00000159335
	ENSMUSG00000030122
	P20962
	Q9D0J8
	NM_002824; NM_001330333
	NM_026988
	NP_001317262; NP_002815
	NP_081264
	Wikidata
View/Edit Human	View/Edit Mouse

Parathymosin is a protein that in humans is encoded by the PTMS gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030122 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martic G, Karetsou Z, Kefala K, Politou AS, Clapier CR, Straub T, Papamarcaki T (Apr 2005). "Parathymosin affects the binding of linker histone H1 to nucleosomes and remodels chromatin structure". J Biol Chem. 280 (16): 16143–50. doi:10.1074/jbc.M410175200. PMID 15716277.
^ "Entrez Gene: PTMS parathymosin".

Hannappel E, Huff T (2003). "The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function". Vitam. Horm. 66: 257–96. doi:10.1016/s0083-6729(03)01007-0. PMID 12852257.
Clinton M, Graeve L, el-Dorry H, et al. (1991). "Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ". Proc. Natl. Acad. Sci. U.S.A. 88 (15): 6608–12. Bibcode:1991PNAS...88.6608C. doi:10.1073/pnas.88.15.6608. PMC 52136. PMID 1862085.
Panneerselvam C, Caldarella J, Horecker BL (1988). "A radioimmunoassay for parathymosin". J. Immunol. Methods. 104 (1–2): 131–6. doi:10.1016/0022-1759(87)90496-0. PMID 2445824.
Clinton M, Frangou-Lazaridis M, Panneerselvam C, Horecker BL (1989). "The sequence of human parathymosin deduced from a cloned human kidney cDNA". Biochem. Biophys. Res. Commun. 158 (3): 855–62. doi:10.1016/0006-291X(89)92801-5. PMID 2537638.
Szabo P, Clinton M, Macera M, Horecker BL (1989). "Localization of the gene coding for parathymosin to chromosome 17 in humans". Cytogenet. Cell Genet. 50 (2–3): 91–2. doi:10.1159/000132730. PMID 2776490.
Kondili K, Tsolas O, Papamarcaki T (1997). "Selective interaction between parathymosin and histone H1". Eur. J. Biochem. 242 (1): 67–74. doi:10.1111/j.1432-1033.1996.0067r.x. PMID 8954154.
Bruniquel D, Borie N, Triebel F (1998). "Genomic organization of the human LAG-3/CD4 locus". Immunogenetics. 47 (1): 96–8. doi:10.1007/s002510050332. PMID 9382927. S2CID 11259106.
Okamoto K, Isohashi F (2000). "Purification and primary structure of a macromolecular-translocation inhibitor II of glucocorticoid-receptor binding to nuclei from rat liver. Inhibitor II is the 11.5-kDa Zn2+-binding protein (parathymosin)". Eur. J. Biochem. 267 (1): 155–62. doi:10.1046/j.1432-1327.2000.00987.x. PMID 10601862.
Vareli K, Frangou-Lazaridis M, van der Kraan I, et al. (2000). "Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication". Exp. Cell Res. 257 (1): 152–61. doi:10.1006/excr.2000.4857. PMID 10854063.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159335 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030122 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15716277-5] Martic G, Karetsou Z, Kefala K, Politou AS, Clapier CR, Straub T, Papamarcaki T (Apr 2005). "Parathymosin affects the binding of linker histone H1 to nucleosomes and remodels chromatin structure". J Biol Chem. 280 (16): 16143–50. doi:10.1074/jbc.M410175200. PMID 15716277.

[entrez-6] "Entrez Gene: PTMS parathymosin".

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References

Further reading